2008

Efimov IR, Nature Versus Nurture in Cardiac Conduction: Toward Integrative Paradigm of Cardiac Tissue Engineering, Circ. Res., Circ. Res. 2008; 103;119-121. [pdf]

Hucker WJ, Fedorov VV, Foyil KV, Moazami N, Efimov IR, Optical Mapping of the Human Atrioventricular Junction, Circulation, 2008, 117(11): 1474-7.[pdf]

Fedorov VV, Kostecki G, Hemphill M, Efimov IR, Atria are more susceptible to electroporation than ventricles: Implications for atrial stunning, shock-induced arrhythmia and defibrillation failure, Heart Rhythm J., 2008, 5(4): 593-604. [pdf]

Li J, Greener ID, Inada S, Nikolski VP, Yamamoto M, Billeter R, Efimov IR, Dobrzynski H, Boyett MR, Computer three-dimensional reconstruction of the atrioventricular node, Circ. Res., 2008, 102: 975-985. [pdf]

Hucker WJ, McCain ML, Laughner JI, Iaizzo PA, Efimov IR, Connexin 43 Expression Delineates Two Discrete Pathways in the Human Atrioventricular Junction, Anat. Rec., 2008, 291(2): 204-15. [pdf]

Fedorov VV, Nikolski VP, Efimov IR. Effect of electroporation on cardiac electrophysiology. Methods Mol Biol. 2008; 423: 433-48. [pdf]

Fleming C, Ripplinger CM, Webb B, Efimov IR, Rollins AM, Quantification of Cardiac Fiber Orientation Using Optical Coherence Tomography, J Biomed. Opt., 2008, in press.

Kim SC, Vasanji A, Efimov IR, Cheng Y, Spatial Distribution and Extent of Electroporation by Strong Internal Shock in Intact Structurally Normal and Chronically Infarcted Rabbit Hearts, JCE, 2008, in press.

Kroll MW, Ho JD, Williams HE, Panescu D, Efimov IR, Luceri RM, Tchou PJ, Calkins H, Increasing Accuracy in Autopsy Reports of Custody-Related Deaths Where a Conducted Electrical Weapon was Used: A Cardiovascular Perspective. J. Forensic Sci. 2008, subm.

Hucker WJ, Ripplinger CM, Fleming CP, Fedorov VV, Rollins AM, Efimov IR, Bimodal Biophotonic Imaging of the Structure-Function: Relationship in Cardiac Tissue, J. Biomed. Opt., 2008, in press.

2007

Sharma V, Qu F, Nikolski VP, DeGroot P, Efimov IR, Direct Measurements of Membrane Time Constant During Defibrillation Strength Shocks, Heart Rhythm, 2007, 4(4): 478-86. [pdf]

Fedorov VV, Lozinsky IT, Sosunov EA, Anyukhovsky EP, Rosen MR, Balke WC, Efimov IR, Application of blebbistatin as an excitation-contraction uncoupler for electrophysiological study of rat and rabbit hearts, Heart Rhythm, 2007 May;4(5):619-26. [pdf][pdf]

 Efimov IR, Innovation in optical imaging: looking inside the heart, Heart Rhythm, 2007 Jul;4(7): 925-6. Editorial.

Ryu K, Li L, Khrestian C, Matsumoto N, Sahadevan J, Ruehr M, Van Wagoner D, Efimov IR, Waldo, A. Effects of Sterile Pericarditis on Connexins 40 and 43 in the Atria: Correlation with Abnormal Conduction and Atrial Arrhythmias. Am. J. Physiol. Heart Circ. Physiol. 2007, 293(2): H1231-41.[pdf]

Van Der Heyden MAG, Kok B, Kouwenhoven EN, Toien O, Barnes BM, Fedorov VG, Efimov IR, Opthof T, Cloning, sequence analysis and phylogeny of Connexin43 isolated from American black bear heart. DNA sequence. 2007, 18(5): 380-4. [pdf]

 Qu F, Ripplinger CM, Nikolski VP, Grimm C, Efimov IR, Three Dimensional Panoramic Imaging of Cardiac Arrhythmias in the Rabbit Heart. J. Biomed. Opt. 2007, 12(4): 044019. [pdf]

Hucker WJ, Sharma V, Nikolski VP, Efimov IR, Atrio-Ventricular Conduction with and without AV Nodal Delay: Two Pathways to the Bundle of His in the Rabbit Heart. Am. J. Physiol. Heart Circ. Physiol. 2007, 293(2): H1122-30. [pdf]

Hucker WJ, Nikolski VP, Efimov IR, Autonomic Control and Innervation of the AV Junctional Pacemaker. Heart Rhythm, 2007, 4: 1326-1335. [pdf]

Filas BA, Efimov IR, Taber LA, Optical Coherence Tomography as a Tool for Measuring Morphogenetic Deformation of the Looping Heart, Anatomical Records, 2007, 290(9): 1057-68. [pdf]

Glukhov AV, Egorov IuV, Fedorov VV, Efimov IR, Rozenshtraukh LV. The effect of hypothermia on the wavelength and vulnarability to ventricular arrhythmias in mammals. Ross Fiziol Zh Im I M Sechenova. 2007 Mar; 93(3):289-99. Russian.

Bishop MJ, Rodriguez B, Qu F, Efimov IR, Gavaghan DJ, Trayanova NA, Synthesis Of Optical Recordings During Arrhythmia And Defibrillation: An Inquiry Into The Role Of Photon Scattering In Signal Distortion. Biophys. J., 2007, 93(10): 3714-26. [pdf]

Ripplinger CM, Li W, Hadley J, Chen J, Rothenberg F, Lombardi R, Wickline SA, Marian AJ, Efimov IR, Enhanced transmural fiber rotation and Cx43 heterogeneity are associated with an increased upper limit of vulnerability in a transgenic rabbit model of human hypertrophic cardiomyopathy, Circulation Research, 2007, 101(10): 1049-57. [pdf]

2006

Rothenberg F, Efimov IR, Three-Dimensional Anatomy of the Conduction System of the Early Embryonic Rabbit Heart, Anatomical records, 2006 288A:3-7.

Efimov IR, Ripplinger CM, Tornado in a dish: revealing the mechanisms of ventricular arrhythmias in engineered cardiac tissues, Cardiovascular Research, 2006, 69(2): 307-8, Editorial.

Efimov IR, Fedorov VV, Precordial thump and commotio cordis: The yin and yang of mechanoelectric feedback in the heart, Heart Rhythm, 2006, 3(2): 187-188. Editorial.

Jenkins MW, Rothenberg F, Roy D, Nikolski VP, Watanabe M, Wilson DL, Efimov IR, Rollins AM, Embryonic Cardiography using Gated Optical Coherence Tomography, Optics Express, 2006, 14(2): 736-748.

Ripplinger CM, Krinsky VI, Nikolski VP, Efimov IR, Mechanisms of unpinning and termination of ventricular tachycardia: Implications for low voltage defibrillation. Am. J. Physiol., 2006, 291(1): H184-92.

Kroll MW, Efimov IR, Tchou PJ, Present understanding of shock polarity for internal defibrillation: the obvious and non-obvious clinical implications. Pacing Clin. Electrophysiol. 2006 Aug; 29(8):885-91.

Fedorov VV, Hucker WJ, Dobrzynski H, Efimov IR, Postganglionic nerve stimulation induces temporal inhibition of excitability in rabbit sinoatrial node. Am J Physiol Heart Circ Physiol. 2006 Aug; 291(2): H612-23.

Boyett MR, Inada S, Yoo S, Li J, Liu J, Tellez J, Greener ID, Honjo H, Billeter R, Lei M, Zhang H, Efimov IR, Dobrzynski H. Connexins in the sinoatrial and atrioventricular nodes. Adv Cardiol. 2006; 42:175-97.

Efimov IR, Ripplinger CM, Virtual electrode hypothesis of defibrillation. Heart Rhythm. 2006 Sep;3(9): 1100-2. Epub 2006 Mar 10.

Nikolskaya AV, Nikolski VP, Efimov IR, Gene printer: laser-scanning targeted transfection of cultured cardiac neonatal rat cells. Cell Commun Adhes. 2006 Jul-Aug; 13(4):217-22.

Yoo S, Dobrzynski H, Fedorov VV, Xu SZ, Yamanushi TT, Jones SA, Yamamoto M, Nikolski VP, Efimov IR, Boyett MR. Localization of Na+ Channel Isoforms at the Atrioventricular Junction and Atrioventricular Node in the Rat. Circulation. 2006 Sep 11;

2005

Nikolski VP, Efimov IR, Electroporation of the heart. Europace. 2005 (Suppl 2): 146-54. 

Hucker WJ, Nikolski VP, Efimov IR, Optical mapping of the atrioventricular junction. J. Electrocardiology, 2005, 38S: 121-5. Review.

Efimov IR, Fedorov VV, Chessboard of atrial fibrillation: Reentry or focus? Single or multiple source(s)? Neurogenic or myogenic? Am. J. Physiol, 2005, 289(3): H977-9.  Editorial comment.

Fedorov VV, Li L, Glukhov A, Shishkina I, Aliev RP, Mikheeva T, Nikolski VP, Rosenshtraukh LV, Efimov IR. Hibernator Citellus undulatus maintains safe cardiac conduction and is protected against tachyarrhythmias during extreme hypothermia: possible role of Cx43 and Cx45 upregulation. Heart Rhythm., 2005, 2(9): 966-75. [Cover page]. 

Deng, CX, Qu F, Nikolski VP, Zhou Y, Efimov IR, Fluorescent real-time monitoring of cardiac high-intensity focused ultrasound ablation. Ann. Biomed. Eng, 2005, 33(10): 1417-1424.

Rodriguez B, Li L, Eason JC, Efimov IR, Trayanova NA. Differences Between Left and Right Ventricular Chamber Geometry Affect Cardiac Vulnerability to Electric Shocks. Circ Res. 2005; 97(2): 168-75. [Cover page]

Dobrzynski H, Li J, Tellez J, Greener ID, Nikolski VP, Wright SE, Parson SH, Jones SA, Lancaster MK, Yamamoto M, Honjo H, Takagishi Y, Kodama I, Efimov IR, Billeter R, Boyett MR. Computer three-dimensional reconstruction of the sinoatrial node. Circulation. 2005; 111: 846-854.

Jenkins M, Wade RS, Cheng Y, Rollins AM, Efimov IR. Optical coherence tomography imaging of the Purkinje network. J Cardiovasc Electrophysiol. 2005; 16: 559-560.

Li L, Nikolski V, Wallick DW, Efimov IR, Cheng Y. Mechanisms of enhanced shock-induced arrhythmogenesis in the rabbit heart with healed myocardial infarction. Am J Physiol: Heart Circ Physiol. 2005, 289(3): H1054-68.

Qu F, Li L, Nikolski V, Sharma V, Efimov IR. Mechanisms of Superiority of Ascending Ramp Waveforms: New Insights into Mechanisms of Shock-induced Vulnerability and Defibrillation. Am J Physiol: Heart Circ Physiol. 2005; 289(2): H569-77.

Qu F, Zarubin F, Wollenzier B, Nikolski VP, Efimov IR. The Gurvich waveform has lower defibrillation threshold than the rectilinear waveform and the truncated exponential waveform in the rabbit heart. Can J Physiol Pharmacol. 2005; 83: 152-160.

Rothenberg F, Nikolski VP, Watanabe M, Efimov IR. Electrophysiology and anatomy of embryonic rabbit hearts before and after septation. Am J Physiol: Heart Circ Physiol. 2005; 288: H344-H351. [Cover page]

Rozenshtraukh LV, Fedorov VV, Aliev RR, Glukhov AV, Mikheeva TV, Reznik AV, Efimov IR. [Pattern of Excitation in Isolated Heart of Hibernator Ground Squirrel Citellus undulatus]. Kardiologiia. 2005; 45: 4-10.

2004

Efimov IR, Nikolski VP, Rothenberg F, Greener ID, Li J, Dobrzynski H, Boyett M. Structure-function relationship in the AV junction. Anat Rec A Discov Mol Cell Evol Biol. 2004; 280: 952-965.

Nikolski VP, Sambelashvili AT, Krinsky VI, Efimov IR. Effects of electroporation on optically recorded transmembrane potential responses to high-intensity electrical shocks. Am J Physiol Heart Circ Physiol. 2004; 286: H412-H418.

Pazo D, Kramer L, Pumir A, Kanani S, Efimov I, Krinsky V. Pinning force in active media. Phys Rev Lett. 2004; 93: 168303.

Rothenberg F, Efimov IR, Watanabe M. Functional imaging of the embryonic pacemaking and cardiac conduction system over the past 150 years: technologies to overcome the challenges. Anat Rec A Discov Mol Cell Evol Biol. 2004; 280: 980-989.

Sambelashvili A, Efimov IR. Dynamics of virtual electrode-induced scroll-wave reentry in a 3D bidomain model. Am J Physiol Heart Circ Physiol. 2004; 287: H1570-H1581.

Sambelashvili AT, Nikolski VP, Efimov IR. Virtual electrode theory explains pacing threshold increase caused by cardiac tissue damage. Am J Physiol Heart Circ Physiol. 2004; 286: H2183-H2194.

Takagi S, Pumir A, Pazo D, Efimov I, Nikolski V, Krinsky V. Unpinning and removal of a rotating wave in cardiac muscle. Phys Rev Lett. 2004; 93: 058101.

Takagi S., Pumir A., Pazo D., Efimov I., Nikolski V., Krinsky V., A physical approach to remove anatomical reentries: a bidomain study. J. Theor. Biol., 2004, 230(4): 489-497.

Efimov IR, Nikolski VP, Salama G. Optical imaging of the heart. Circ Res. 2004 Jul 9; 95(1): 21-33

Cheng Y, Li L, Nikolski V, Wallick DW, Efimov IR. Shock-induced arrhythmogenesis is enhanced by 2,3-butanedione monoxime compared with cytochalasin D.Am J Physiol Heart Circ Physiol. 2004; 286(1): H310-8. Epub 2003 Sep 04

2003

Li L, Nikolski V, Efimov IR. Effects of lidocaine on shock-induced vulnerability. J Cardiovasc Electrophysiol. 2003; 14(10 Suppl): S237-48.

Efimov IR, Nikolski VP. Diastolic shocking experience: do virtual electrodes exist only during systole? J Cardiovasc Electrophysiol. 2003; 14(11): 1223-4.

Dobrzynski H, Nikolski VP, Sambelashvili AT, Greener ID, Yamamoto M, Boyett MR, Efimov IR. Site of origin and molecular substrate of atrioventricular junctional rhythm in the rabbit heart. Circ Res. 2003; 93(11): 1102-10.

Efimov IR. Fibrillation or neurillation: back to the future in our concepts of sudden cardiac death? Circ Res. 2003; 92(10): 1062-4.

Sambelashvili AT, Nikolski VP, Efimov IR. Nonlinear effects in subthreshold virtual electrode polarization. Am J Physiol Heart Circ Physiol. 2003; 284(6): H2368-74.

Garrigue S, Reuter S, Efimov IR, Mazgalev TN, Jais P, Haissaguerre M, Clementy J. Optical mapping technique applied to biventricular pacing: potential mechanisms of ventricular arrhythmias occurrence. Pacing Clin Electrophysiol. 2003; 26(1 Pt 2): 197-205.

Nikolski VP, Jones SA, Lancaster MK, Boyett MR, Efimov IR. Cx43 and dual-pathway electrophysiology of the atrioventricular node and atrioventricular nodal reentry. Circ Res. 2003; 92(4): 469-75.

Efimov I.R., Mowrey K.A., Cheng Y., Tchou P.J., Letter to editor, EuroPACE, 2003, 5(3): 243-244.

2002

Nikolski V, Sambelashvili A, Efimov IR. Anode-break excitation during end-diastolic stimulation is explained by half-cell double layer discharge. IEEE Trans Biomed Eng. 2002 Oct;49(10):1217-20.

Efimov IR. Virtual electrodes in virtual reality of defibrillation. J Cardiovasc Electrophysiol. 2002 Jul;13(7):680-1.

Cheng Y, Mowrey KA, Nikolski V, Tchou PJ, Efimov IR. Mechanisms of shock-induced arrhythmogenesis during acute global ischemia. Am J Physiol Heart Circ Physiol. 2002 Jun;282(6):H2141-51.

Gupta M, Rollins AM, Izatt JA, Efimov IR.  Imaging of the atrioventricular node using optical coherence tomography. J Cardiovasc Electrophysiol. 2002 Jan;13(1):95.

Sambelashvili A, Efimov IR. The pinwheel experiment re-revisited. J Theor Biol. 2002 Jan 21;214(2):147-53.

Nikolski VP, Sambelashvili AT, Efimov IR. Mechanisms of make and break excitation revisited: paradoxical break excitation during diastolic stimulation. Am J Physiol Heart Circ Physiol. 2002 Feb;282(2):H565-75.

Mowrey KA, Cheng Y, Tchou PJ, Efimov R. Kinetics of defibrillation shock-induced response: design implications for the optimal defibrillation waveform. Europace. 2002 Jan;4(1):27-39.

Dumitrescu C, Narayan P, Efimov IR, Cheng Y, Radin MJ, McCune SA, Altschuld RA. Mechanical alternans and restitution in failing SHHF rat left ventricles. Am J Physiol Heart Circ Physiol. 2002 Apr;282(4):H1320-6.

Dumitrescu C, Narayan P, Cheng Y, Efimov IR, Altschuld RA. Phase I and phase II of short-term mechanical restitution in perfused rat left ventricles. Am J Physiol Heart Circ Physiol. 2002 Apr;282(4):H1311-9.

Efimov I.R., Cheng, Y., Sambelashvili A., Nikolski V., The progress in studies of mechanisms of electrical stimulation of the heart. Part 3. Defibrillation. Journal of Arrhythmology, 2002, 29: 75-80.

Efimov I.R., Cheng, Y., Sambelashvili A., Nikolski V., The progress in studies of mechanisms of electrical stimulation of the heart. Part 2. Arrhythmogenesis. Journal of Arrhythmology, 2002, 28: 79-83.

Efimov I.R., Sambelashvili A., Nikolski V., The progress in studies of mechanisms of electrical stimulation of the heart. Part 1. Point stimulation. Journal of Arrhythmology, 2002, 26: 91-96.

2001

Nikolski V, Efimov I. Fluorescent imaging of a dual-pathway atrioventricular-nodal conduction system. Circ Res. 2001 Feb 16;88(3):E23-30.

Yamanouchi Y, Cheng Y, Tchou PJ, Efimov IR. The mechanisms of the vulnerable window: the role of virtual electrodes and shock polarity. Can J Physiol Pharmacol. 2001 Jan;79(1):25-33.

2000

Al-Khadra A, Nikolski V, Efimov IR. The role of electroporation in defibrillation. Circ Res. 2000 Oct 27;87(9):797-804.

Cheng Y, Nikolski V, Efimov IR. Reversal of repolarization gradient does not reverse the chirality of shock-induced reentry in the rabbit heart. J Cardiovasc Electrophysiol. 2000 Sep;11(9):998-1007.

Efimov IR, Aguel F, Cheng Y, Wollenzier B, Trayanova N. Virtual electrode polarization in the far field: implications for external defibrillation. Am J Physiol Heart Circ Physiol. 2000 Sep;279(3):H1055-70.

Efimov IR. A shocking experience: ionic modulation of virtual electrodes in defibrillation. Circ Res. 2000 Sep 15;87(6):429-30.

Efimov IR, Cheng Y, Yamanouchi Y, Tchou PJ. Direct evidence of the role of virtual electrode-induced phase singularity in success and failure of defibrillation. J Cardiovasc Electrophysiol. 2000 Aug;11(8):861-8.

Nikolski V, Efimov IR. Virtual electrode polarization of ventricular epicardium during bipolar stimulation. J Cardiovasc Electrophysiol. 2000 May;11(5):605.

Efimov IR, Gray RA, Roth BJ. Virtual electrodes and deexcitation: new insights into fibrillation induction and defibrillation.J Cardiovasc Electrophysiol. 2000 Mar;11(3):339-53. Review.

Efimov IR, Sidorov, V.Yu. Optical Mapping of Electrical Activity in the Heart, Kardiologiya, 2000, 8: 38-52.