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Publications

2013

Glukhov AV, Uchida K, Efimov IR, Nichols CG.
Functional roles of KATP channel subunits in metabolic inhibition. J Mol Cell Cardiol. 2013 Apr 23. doi:pii: S0022-2828(13)00147-8. 10.1016/j.yjmcc.2013.04.016. [Epub ahead of print] PMID: 23624089.
Liu M, Gu L, Sulkin MS, Liu H, Jeong EM, Greener I, Xie A, Efimov IR, Dudley SC Jr.
Mitochondrial dysfunction causing cardiac sodium channel downregulation in cardiomyopathy. J Mol Cell Cardiol. 2013 Jan;54:25-34. doi: 10.1016/j.yjmcc.2012.10.011. Epub 2012 Nov 1. PMCID: PMC3595554.
Wang Y, Laughner JI, Efimov IR, Zhang S.
3D absolute shape measurement of live rabbit hearts with a superfast two-frequency phase-shifting technique. Opt Express. 2013 Mar 11;21(5):5822-32. doi: 10.1364/OE.21.005822. PMID: 23482151.
Walmsley J, Rodriguez JF, Mirams GR, Burrage K, Efimov IR, Rodriguez B.
mRNA expression levels in failing human hearts predict cellular electrophysiological remodeling: a population-based simulation study. PLoS One. 2013;8(2):e56359. doi: 10.1371/journal.pone.0056359. Epub 2013 Feb 20. PMID: 23437117.
Luo M, Guan X, Luczak ED, Lang D, Kutschke W, Gao Z, Yang J, Glynn P, Sossalla S, Swaminathan PD, Weiss RM, Yang B, Rokita AG, Maier LS, Efimov IR, Hund TJ, Anderson ME.
Diabetes increases mortality after myocardial infarction by oxidizing CaMKII. J Clin Invest. 2013 Mar 1;123(3):1262-74. doi: 10.1172/JCI65268. Epub 2013 Feb 15. PMID: 23426181.
Ambrosi CM, Yamada KA, Nerbonne JM, Efimov IR.
Gender differences in electrophysiological gene expression in failing and non-failing human hearts. PLoS One. 2013;8(1):e54635. doi: 10.1371/journal.pone.0054635. Epub 2013 Jan 23. PMCID: PMC3552854.
Takasu O, Gaut JP, Watanabe E, To K, Fagley RE, Sato B, Jarman S, Efimov IR, Janks DL, Srivastava A, Bhayani SB, Drewry A, Swanson PE, Hotchkiss RS.
Mechanisms of cardiac and renal dysfunction in patients dying of sepsis. Am J Respir Crit Care Med. 2013 Mar 1;187(5):509-17. doi: 10.1164/rccm.201211-1983OC. Epub 2013 Jan 24. PMID: 23348975.

2012

Lou Q, Janardhan A, Efimov IR.
Remodeling of calcium handling in human heart failure. Adv Exp Med Biol. 2012;740:1145-74. PMID: 22453987
Janardhan AH, Li W, Fedorov VV, Yeung M, Wallendorf MJ, Schuessler RB, Efimov IR.
A novel low-energy electrotherapy that terminates ventricular tachycardia with lower energy than a biphasic shock when antitachycardia pacing fails. J Am Coll Cardiol. 2012 Dec 11;60(23):2393-8. doi: 10.1016/j.jacc.2012.08.1001. Epub 2012 Nov 7. PMID: 23141483.
Glukhov AV, Fedorov VV, Kalish PW, Ravikumar VK, Lou Q, Janks D, Schuessler RB, Moazami N, Efimov IR.
Conduction remodeling in human end-stage nonischemic left ventricular cardiomyopathy. Circulation. 2012 Apr 17;125(15):1835-47. Epub 2012 Mar 12. PMID: 22412072.
Laughner JI, Sulkin MS, Wu Z, Deng CX, Efimov IR.
Three Potential Mechanisms for Failure of HIFU Ablation in Cardiac Tissue. Circ Arrhythm Electrophysiol. 2012 Feb 9. [Epub ahead of print] PMID: 22322367.
Nikolaidou T, Aslanidi OV, Zhang H, Efimov IR.
Structure-Function Relationship in the Sinus and Atrioventricular Nodes. Pediatr Cardiol. 2012 Mar 3. [Epub ahead of print] PMID: 22391764.
Lou Q, Janks DL, Holzem K, Lang D, Onal B, Ambrosi CM, Fedorov VV, Wang IW, Efimov IR.
Right Ventricular Arrhythmogenesis in Failing Human Heart: The Role of Conduction and Repolarization Remodeling. Am J Physiol Heart Circ Physiol. 2012 Dec 15;303(12):H1426-34. doi: 10.1152/ajpheart.00457.2012. Epub 2012 Oct 5. PMID: 23042951.
Wang YT, Popović ZB, Efimov IR, Cheng Y.
Longitudinal Study of Cardiac Remodelling in Rabbits Following Infarction. Can J Cardiol. 2012 Jan 20. [Epub ahead of print] PMID: 22265993.
Wang YT, Efimov IR, Cheng Y.
Electroporation Induced by Internal Defibrillation Shock with and without Recovery in Intact Rabbit Hearts. Am J Physiol Heart Circ Physiol. 2012 Jun 22. [Epub ahead of print] PMID: 22730387
Pietka TA, Sulkin MS, Kuda O, Wang W, Zhou D, Yamada KA, Yang K, Su X, Gross RW, Nerbonne JM, Efimov IR, Abumrad NA.
CD36 Protein Influences Myocardial Ca2+ Homeostasis and Phospholipid Metabolism: CONDUCTION ANOMALIES IN CD36-DEFICIENT MICE DURING FASTING. J Biol Chem. 2012 Nov 9;287(46):38901-12. doi: 10.1074/jbc.M112.413609. Epub 2012 Sep 27. PMID: 23019328.
Lou Q, Li W, Efimov IR.
The role of dynamic instability and wavelength in arrhythmia maintenance as revealed by panoramic imaging with blebbistatin vs. 2,3-butanedione monoxime. Am J Physiol Heart Circ Physiol. 2012 Jan;302(1):H262-9. Epub 2011 Oct 28. PMID: 22037192.
Holzem KM, Efimov IR,
Arrhythmogenic remodelling of activation and repolarization in the failing human heart. Europace 2012 Nov;14 Suppl 5:v50-v57. doi: 10.1093/europace/eus275. PMID: 23104915.
Egorov YV, Glukhov AV, Efimov IR, Rosenshtraukh LV,
Hypothermia-induced spatially discordant action potential duration alternans and arrhythmogenesis in non-hibernating versus hibernating mammals. Am J Physiol Heart Circ Physiol. 2012 Oct 15;303(8):H1035-46. doi: 10.1152/ajpheart.00786.2011. Epub 2012 Aug 10. PMID: 22886418
Janardhan AH, Li W, Fedorov VV, Gutbrod SR, Yeung M, Walldorf M, Schuessler RB, Efimov IR.
A Multi-Stage Electrotherapy To Terminate Ventricular Tachycardia With Lower Energy than a Biphasic Shock When Anti-Tachycardia Pacing Fails. JACC, 2012, in press.
Smith AW, Segar CE, Nguyen PK, MacEwan MR, Efimov IR, Elbert DL.
Long-term culture of HL-1 cardiomyocytes in modular poly(ethylene glycol) microsphere-based scaffolds crosslinked in the phase-separated state. Acta Biomater. 2012 Jan;8(1):31-40. Epub 2011 Aug 30. PMID: 21920469
Laughner JI, Ng FS, Sulkin MS, Arthur MA, Efimov IR.
Processing and Analysis of Cardiac Optical Mapping Data Obtained with Potentiometric Dyes. Am J Physiol Heart Circ Physiol. 2012 Oct 1;303(7):H753-65. doi: 10.1152/ajpheart.00404.2012. Epub 2012 Jul 20. PMID: 22821993.
Laughner JI, Zhang S, Li H, Shao CC, Efimov IR.
Mapping cardiac surface mechanics with structured light imaging. Am J Physiol Heart Circ Physiol. 2012 Sep 15;303(6):H712-20. Epub 2012 Jul 13. PMID: 22796539.
Ambrosi CM, Fedorov VV, Schuessler RB, Rollins AM, Efimov IR.
Quantification of Fiber Orientation in the Canine Atrial Pacemaker Complex using Optical Coherence Tomography. J Biomed Opt. 2012 Jul;17(7):071309. PMID: 22894470.
Efimov IR, Gutbrod S.
"Fibrillating atrium: rabbit warren! Not beehive!". J Cardiovasc Electrophysiol. 2013 Mar;24(3):336-7. doi: 10.1111/jce.12044. Epub 2012 Dec 4.
Rantner LJ, Arevalo HJ, Constantino JL, Efimov IR, Plank G, Trayanova NA.
Three-Dimensional Mechanisms of Increased Vulnerability to Electric Shocks in Myocardial Infarction: Altered Virtual Electrode Polarizations and Conduction Delay in the Peri-Infarct Zone. J Physiol. 2012 May 14. [Epub ahead of print] PMID: 22586222.
Efimov IR, Gutbrod S.
Fibrillating Atrium: Rabbit Warren! Not Beehive! J Cardiovasc Electrophysiol. 2012 Oct 22. doi: 10.1111/jce.12044. [Epub ahead of print].

2011

Lang D, Glukhov AV, Efimova T, Efimov IR.
The role of Pyk2 in cardiac arrhythmogenesis, AJP: Heart, 2011, in press. PMID: 21666110.
Quinn TA, Granite S, Allessie MA, Antzelevitch C, Bollensdorff C, Bub G, Burton RAB, Cerbai E, Chen PS, Delmar M, DiFrancesco D, Earm YE, Efimov IR, Egger M, Entcheva E, Fink M, Fischmeister R, Franz MR, Garny A, Giles WR, Hannes T, Harding SE, Hunter PJ, Iribe G, Jalife J, Johnson CR, Kass RS, Kodama I, Koren G, Lord P, Markhasin VS, Matsuoka S, McCulloch AD, Mirams GR, Morley GE, Nattel S, Noble D, Olesen SP, Panfilov AV, Trayanova NA, Ravens U, Richard S, Rosenbaum DS, Rudy Y, Sachs F, Sachse FB, Saint DA, Schotten U, Solovyova O, Taggart P, Tung L, Varró A, Volders PG, Wang K, Weiss JN, White E, Wilders R, Winslow RL, Kohl P,
Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): Standardised Reporting for Model Reproducibility, Interoperability, and Data Sharing, Progress in Biophysics and Molecular Biology, 2011, in press. PMID: 21745496.
Ambrosi CM, Ripplinger CM, Efimov IR, Fedorov VV
Termination of sustained atrial flutter and fibrillation using low energy multiple shock therapy. Heart Rhythm. 2011 Jan;8(1): 101-8. PMID: 20969974.
Greener ID, Monfredi O, Inada S, Chandler NJ, Tellez JO, Atkinson A, Taube MA, Billeter R, Anderson RH, Efimov IR, Molenaar P, Sigg DC, Sharma V, Boyett MR, Dobrzynski H.
Molecular architecture of the human specialised atrioventricular conduction axis. J Mol Cell Cardiol. 2011 Apr;50(4):642-51. PMID: 21256850
Lou Q, Fedorov VV, Glukhov AV, Fast VG, Moazami N, Efimov IR,
Transmural heterogeneity and remodeling of ventricular excitation-contraction coupling in human heart failure. Circulation. 2011 May 3;123(17):1881-90. PMID:21502574.
Fedorov VV, Glukhov AV, Ambrosi CM, Kostecki G, Chang R, Janks D, Schuessler RB, Moazami N, Nichols CG, Efimov IR.
Effects of KATP channel openers diazoxide and pinacidil in coronary-perfused atria and ventricles from failing and non-failing human hearts. J Mol Cell Cardiol. 2011 Aug;51(2):215-25. PMID:21586291.
Li W, Janardhan AH, Fedorov VV, Sha Q, Schuessler RB, Efimov IR.
Low-energy multistage atrial defibrillation therapy terminates atrial fibrillation with less energy than a single shock. Circ Arrhythm Electrophysiol. 2011 Dec;4(6):917-25. Epub 2011 Oct 6. PMID: 21980076.
Lou Q, Li W, Efimov IR
Multiparametric Optical Mapping of the Langendorff-perfused Rabbit Heart. J. Vis. Exp. (55), e3160, DOI: 10.3791/3160 (2011).
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Lang D, Petrov V, Lou Q, Osipov G, Efimov IR.
Spatiotemporal control of heart rate in a rabbit heart. J Electrocardiol. 2011 Nov-Dec;44(6):626-34. Epub 2011 Sep 19. PMID: 21937057
Lang D, Sulkin M, Lou Q, Efimov IR
Optical Mapping of Action Potentials and Calcium Transients in the Mouse Heart. J. Vis. Exp. (55), e3275, DOI: 10.3791/3275 (2011).
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Fedorov VV, Ambrosi CM, Kostecki G, Hucker WJ, Glukhov AV, Wuskell J, Loew LM, Moazami N, Efimov IR,
Anatomic localization and autonomic modulation of atrioventricular junctional rhythm in failing human hearts. Circ Arrhythm Electrophysiol. 2011 Aug;4(4):515-25. Epub 2011 Jun 6. PMID: 21646375.
Swaminathan PD, Purohit A, Soni S, Voigt N, Singh MV, Glukhov AV, Gao Z, He JB, Luczak ED, Joiner MA, Kutschke W, Yang J, Donahue JK, Weiss RM, Grumbach IM, Ogawa M, Chen PS, Efimov IR, Dobrev D, Mohler PJ, Hund TJ, Anderson ME,
Oxidized CaMKII causes cardiac sinus node dysfunction in mice, J Clin Invest. 2011 Aug;121(8):3277-88. Epub 2011 Jul 25. PMC3223923.
Bordas R, Gillow K, Lou Q, Efimov IR, Gavaghan D, Kohl P, Grau V, Rodriguez B,
Full Rabbit-Specific Ventricular Model of Cardiac Electrophysiological Function including Specialized Conduction System, Progress in Biophysics and Molecular Biology, 2011. PMID: 21672547.

2010

Gronich N, Kumar A, Zhang Y, Efimov IR, Soldatov NM
Molecular remodeling of ion channels, exchangers and pumps in atrial and ventricular myocytes in ischemic cardiomyopathy, Channels, 2010, 18;4(2). PMID: 20090424.
2010-Gronich-NIH.pdf
Glukhov AV, Fedorov VV, Anderson ME, Mohler PJ, Efimov IR
Functional Anatomy Of The Murine Sinus Node: High-Resolution Optical Mapping Of Ankyrin-B Heterozygous Mice, AJP, 2010 Aug; 299(2): H482-91. PMID: 20525877.
Glukhov AV, Flagg TP, Fedorov VV, Efimov IR, Nichols CG
Differential KATP channel pharmacology in intact mouse heart. J Mol Cell Cardiol. 2010 Jan; 48(1): 152-60. PMID: 19744493.
Efimov IR, Fedorov VV, Joung B, Lin SF
Mapping Cardiac Pacemaker Circuits: Methodological Puzzles of the Sino-Atrial Node Optical Mapping, Circ Res. 2010, 106(2):255-71. PMID: 20133911
2010-Efimov-JAHA.pdf
Kurian TK, Efimov IR
Mechanisms of fibrillation: neurogenic or myogenic? Reentrant or focal? Multiple or single? Still puzzling after 160 years of inquiry. J Cardiovasc Electrophysiol. 2010, 21(11): 1274-5. PMID: 20550608
2010-Kurian-JCE.pdf
Fedorov VV, Glukhov AV, Chang R, Kostecki G, Aferol1 H, Hucker WJ, Wuskell J, Loew LM, Schuessler RB; Moazami N, Efimov IR
Optical mapping of the isolated coronary-perfused human sinus node, JACC, 2010; 56 (17), 1386-1394. PMID: 20946995.
Efimov IR, Fedorov VV, Glukhov A, Lou Q, Ambrosi C, Janks D, Hucker WJ, Kurian T, Schuessler RB, Moazami N.
Multiscale imaging of the human heart: Building the foundation for human systems physiology and translational medicine. Conf Proc IEEE Eng Med Biol Soc. 2010;2010:5177-80. PMID: 21095821.
Fedorov VV, Chang R, Glukhov AV, Kostecki G, Janks D, Schuessler RB, Efimov IR
Complex interactions between the sinoatrial node and atrium during reentrant arrhythmias in the canine heart. Circulation. 2010; 122(8): 782-9. PMID: 20697021
2010-Federov-JAHA.pdf
Laughner JI, Gong Y, Filas BA, Zhang S, Efimov IR.
Structured light imaging of epicardial mechanics. Conf Proc IEEE Eng Med Biol Soc. 2010;2010:5157-60. PMID: 21095816.
Glukhov AV, Fedorov VV, Lou Q, Ravikumar VK, Kalish PW, Schuessler RB, Moazami N, Efimov IR
Transmural Dispersion Of Repolarization In Failing And Non Failing Human Ventricle. Circ Res. 2010; 106(5): 981-91. PMID: 20093630.
Kurian T, Ambrosi C, Hucker W, Fedorov VV, Efimov IR
Anatomy and Electrophysiology of the Human AV Node, Pacing Clin. Electrophysiol. Review. 2010, 33(6): 754-62. PMID: 20180918

2009

Cakulev I, Efimov IR, Waldo AL
Cardioversion: History, Present and Future, Circulation, 2009; 120; 1623-1632. PMID: 19841308
2009-Cakulev-JAHA.pdf
Li W, Ripplinger CM, Lou Q, Efimov IR
Multiple Monophasic Shocks Improve Electrotherapy of Ventricular Tachycardia in a Rabbit Model of Chronic Infarction. Heart Rhythm, 2009 6(7): 1020-7. PMID: 19560090.
Ambrosi CM, Moazami N, Rollins AM, Efimov IR
Virtual Histology of the Human Heart Using Optical Coherence Tomography, JBO, 2009 Sep-Oct; 14(5): 054002. PMID: 19895104.
2009-Ambrosi-JBO.pdf
Fedorov VV, Schuessler RB, Hemphill M, Ambrosi CM, Chang R, Voloshina AS, Brown K, Hucker WJ, Efimov IR
Structural and Functional Evidence for Discrete Exit Pathways that Connect the Canine Sino-Atrial Node and Atria, Circ. Res. 2009, 104(7): 915-23. PMID: 19246679.
2009-Fedorov-JAHA.pdf
Tereshchenko LG, Faddis MN, Fetics BJ, Zelik KE, Efimov IR, Berger RD
Transient Local Injury Current in Right Ventricular Electrogram after ICD Shock Predicts Heart Failure Progression, JACC, 2009 54(9): 822-8. PMID: 19695461.
2009-Tereshchenko-JACC.pdf
Efimov IR
Naum Lazarevich Gurvich (1905-1981) and his contribution to the history of defibrillation. Cardiology Journal, 2009, 16 (2): 190-3. PMID: 19387971.
2009-Efimov-CardiolJ.pdf
Egorov IuV, Glukhov AV, Artiukhov VS, Efimov IR, Rozenshtraukh LV. Ross Fiziol Zh Im I M Sechenova
Comparative study of cardiac alternans of action potential duration in hypothermia in rabbits and ground squirrels, 2009 95(5):532-42. Russian. PMID: 19569529
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Lombardi R, Rodriguez G, Chen SN, Ripplinger CM, Li W, Chen J, Willerson JT, Betocchi S, Wickline SA, Efimov IR, Marian AJ
Resolution of Established Cardiac Hypertrophy and Fibrosis and Preventions of Heart Failure in a Transgenic Rabbit Model of Human Cardiomyopathy Through Thiol-sensitive Mechanisms, Circulation, 2009, 119(10): 1398-407. PMID: 19255346.
Efimov IR
Chronaxie of Defibrillation: A pathway toward further optimization of defibrillation waveform? JCE, 2009, 20(3): 315-7. PMID: 19175836.
2009-Efimov-JCE.pdf
Mowrey KA, Efimov IR, Cheng Y
Membrane time constant during internal defibrillation strength shocks in intact heart: Effects of Na+ and Ca2+ channel blockers, JCE, 2009, 20(1): 85-92. PMID: 18775052.
2009-Mowrey-JCE.pdf
Ripplinger CM, Lou Q, Li W, Hadley J, Efimov IR
Panoramic Imaging Reveals Basic Mechanisms Of Induction and Termination of Ventricular Tachycardia in Rabbit Heart with Chronic Infarction: Implications for Low Voltage Cardioversion, Heart Rhythm, 2009 6(1): 87-97. PMID: 18996057.

2008

Fedorov VV, Nikolski VP, Efimov IR
Effect of electroporation on cardiac electrophysiology. Methods Mol Biol. 2008; 423: 433-48.
2008-Fedorov-MMB.pdf
Fedorov VV, Glukhov AV, Sudharshan S, Egorov Y, Rosenshtraukh LV, Efimov IR
Electrophysiological mechanisms of antiarrhythmic protection during hypothermia in winter hibernating versus nonhibernating mammals. Heart Rhythm, 2008 Nov; 5(11): 1587-96. PMID: 18984537
Hucker WJ, Fedorov VV, Foyil KV, Moazami N, Efimov IR
Optical Mapping of the Human Atrioventricular Junction, Circulation, 2008, 117(11): 1474-7
2008-Hucker-Circ-1474.pdf
Fleming C, Ripplinger CM, Webb B, Efimov IR, Rollins AM
Quantification of Cardiac Fiber Orientation Using Optical Coherence Tomography, J Biomed. Opt., 2008, 13(3): 030505. PMID: 18601522.
2008-Fleming-JPO.pdf
Glukhov AV, Egorov IuV, Efimov IR, Rozenshtraukh LV
Spatiotemporal characteristics of activation of the heart of hibernating and non-hibernating mammals during hypothermia. Kardiologiia. 2008; 48(12): 34-41. In Russian.
Fedorov VV, Kostecki G, Hemphill M, Efimov IR
Atria are more susceptible to electroporation than ventricles: Implications for atrial stunning, shock-induced arrhythmia and defibrillation failure, Heart Rhythm J., 2008, 5(4): 593-604
2008-Fedorov-HR.pdf
Kim SC, Vasanji A, Efimov IR, Cheng Y
Spatial Distribution and Extent of Electroporation by Strong Internal Shock in Intact Structurally Normal and Chronically Infarcted Rabbit Hearts, JCE, 2008, 19(10):1080-9. PMID: 18479336.
Varma N, Efimov I
Right pectoral implantable cardioverter defibrillators: role of the proximal (SVC) coil. Pacing Clin Electrophysiol. 2008 Aug;31(8):1025-35. PMID: 18684259
2008-Varma-PCE.pdf
Hucker WJ, Ripplinger CM, Fleming CP, Fedorov VV, Rollins AM, Efimov IR
Bimodal Biophotonic Imaging of the Structure-Function: Relationship in Cardiac Tissue, J. Biomed. Opt., 2008 Sep-Oct; 13(5): 054012.
2008-Hucker-JBO.pdf
Li J, Greener ID, Inada S, Nikolski VP, Yamamoto M, Billeter R, Efimov IR, Dobrzynski H, Boyett MR
Computer three-dimensional reconstruction of the atrioventricular node, Circ. Res., 2008, 102: 975-985.
2008-Li-CircRes.pdf
Efimov IR
Nature Versus Nurture in Cardiac Conduction: Toward Integrative Paradigm of Cardiac Tissue Engineering, Circ. Res., 2008; 103;119-121.
2008-Efimov-JAHA.pdf
Lou Q, Ripplinger CM, Bayly PV, Efimov IR
Quantitative Panoramic Imaging of Epicardial Electrical Activity. Ann. Biomed. Eng. 2008; 36(10): 1649-58. PMID: 18654852.
Hucker WJ, McCain ML, Laughner JI, Iaizzo PA, Efimov IR
Connexin 43 Expression Delineates Two Discrete Pathways in the Human Atrioventricular Junction, Anat. Rec., 2008, 291(2): 204-15.
2008_AR_Hucker.pdf

2007

Ryu K, Li L, Khrestian C, Matsumoto N, Sahadevan J, Ruehr M, Van Wagoner D, Efimov IR, Waldo, A
Effects of Sterile Pericarditis on Connexins 40 and 43 in the Atria: Correlation with Abnormal Conduction and Atrial Arrhythmias. Am. J. Physiol. Heart Circ. Physiol. 2007, 293(2): H1231-41
2007-Rye-AJP.pdf
Van Der Heyden MAG, Kok B, Kouwenhoven EN, Toien O, Barnes BM, Fedorov VG, Efimov IR, Opthof T
Cloning, sequence analysis and phylogeny of Connexin43 isolated from American black bear heart. DNA sequence. 2007, 18(5): 380-4
2007-Bear-Cx43-DNASeq07.pdf
Qu F, Ripplinger CM, Nikolski VP, Grimm C, Efimov IR
Three Dimensional Panoramic Imaging of Cardiac Arrhythmias in the Rabbit Heart. J. Biomed. Opt. 2007, 12(4): 044019.
2007-Qu-JBO044019.pdf
Hucker WJ, Sharma V, Nikolski VP, Efimov IR
Atrio-Ventricular Conduction with and without AV Nodal Delay: Two Pathways to the Bundle of His in the Rabbit Heart. Am. J. Physiol. Heart Circ. Physiol. 2007, 293(2): H1122-30.
2007-Hucker-AJP-H1122.pdf
Hucker WJ, Nikolski VP, Efimov IR
Autonomic Control and Innervation of the AV Junctional Pacemaker. Heart Rhythm, 2007, 4: 1326-1335.
2007-Hucker-HR.pdf
Filas BA, Efimov IR, Taber LA
Optical Coherence Tomography as a Tool for Measuring Morphogenetic Deformation of the Looping Heart, Anatomical Records, 2007, 290(9): 1057-68.
2007-Filas-AnRec.pdf
Igor Efimov
How to fix a broken heart: Modern Bioengineering Approaches to Cardiovascular Diseases, from Molecules to Patients», Club Bilingua, Moscow, Russia, September 12, 2007
Glukhov AV, Egorov IuV, Fedorov VV, Efimov IR, Rozenshtraukh LV
The effect of hypothermia on the wavelength and vulnarability to ventricular arrhythmias in mammals. Ross Fiziol Zh Im I M Sechenova. 2007 Mar; 93(3):289-99. Russian.
2006-Kroll-PCE.pdf
Bishop MJ, Rodriguez B, Qu F, Efimov IR, Gavaghan DJ, Trayanova NA
Synthesis Of Optical Recordings During Arrhythmia And Defibrillation: An Inquiry Into The Role Of Photon Scattering In Signal Distortion. Biophys. J., 2007, 93(10): 3714-26.
2007-Bishop-BJ.pdf
Sharma V, Qu F, Nikolski VP, DeGroot P, Efimov IR
Direct Measurements of Membrane Time Constant During Defibrillation Strength Shocks, Heart Rhythm, 2007, 4(4): 478-86.
2007-Sharma-HR.pdf
Ripplinger CM, Li W, Hadley J, Chen J, Rothenberg F, Lombardi R, Wickline SA, Marian AJ, Efimov IR
Enhanced transmural fiber rotation and Cx43 heterogeneity are associated with an increased upper limit of vulnerability in a transgenic rabbit model of human hypertrophic cardiomyopathy, Circulation Research, 2007, 101(10): 1049-57.
2007-Ripplinger-CircRes.pdf
Fedorov VV, Lozinsky IT, Sosunov EA, Anyukhovsky EP, Rosen MR, Balke WC, Efimov IR
Application of blebbistatin as an excitation-contraction uncoupler for electrophysiological study of rat and rabbit hearts, Heart Rhythm, 2007 May;4(5):619-26.
2007_HR_Fedorov.pdf
2007_HR_Li and Nattel.pdf
Efimov IR
Innovation in optical imaging: looking inside the heart, Heart Rhythm, 2007 Jul;4(7): 925-6. Editorial.
2007-Efimov-HR.pdf

2006

Boyett MR, Inada S, Yoo S, Li J, Liu J, Tellez J, Greener ID, Honjo H, Billeter R, Lei M, Zhang H, Efimov IR, Dobrzynski H
Connexins in the sinoatrial and atrioventricular nodes. Adv Cardiol. 2006; 42:175-97.
2006-Boyett-AC.pdf
Efimov IR, Ripplinger CM
Virtual electrode hypothesis of defibrillation. Heart Rhythm. 2006 Sep;3(9): 1100-2. Epub 2006 Mar 10.
2006-Efimov-HR.pdf
Efimov IR, Fedorov VV
Precordial thump and commotio cordis: The yin and yang of mechanoelectric feedback in the heart, Heart Rhythm, 2006, 3(2): 187-188. Editorial.
2006-Efimov-HR2.pdf
Nikolskaya AV, Nikolski VP, Efimov IR
Gene printer: laser-scanning targeted transfection of cultured cardiac neonatal rat cells. Cell Commun Adhes. 2006 Jul-Aug; 13(4):217-22.
2006-Nikolskaya-IH.pdf
Jenkins MW, Rothenberg F, Roy D, Nikolski VP, Watanabe M, Wilson DL, Efimov IR, Rollins AM
Embryonic Cardiography using Gated Optical Coherence Tomography, Optics Express, 2006, 14(2): 736-748.
2006-Jenkins-OSA.pdf
Yoo S, Dobrzynski H, Fedorov VV, Xu SZ, Yamanushi TT, Jones SA, Yamamoto M, Nikolski VP, Efimov IR, Boyett MR
Localization of Na+ Channel Isoforms at the Atrioventricular Junction and Atrioventricular Node in the Rat. Circulation. 2006 Sep 11;
Rothenberg F, Efimov IR
Three-Dimensional Anatomy of the Conduction System of the Early Embryonic Rabbit Heart, Anatomical records, 2006 288A:3-7.
2006-Rothenberg-ARP.pdf
Ripplinger CM, Krinsky VI, Nikolski VP, Efimov IR
Mechanisms of unpinning and termination of ventricular tachycardia: Implications for low voltage defibrillation. Am. J. Physiol., 2006, 291(1): H184-92.
2006-Ripplinger-AJPhys.pdf
Igor Efimov
Reentrant Arrhythmias, Mathematical Biosciences Institute, Columbus, OH. September 28, 2006
Kroll MW, Efimov IR, Tchou PJ
Present understanding of shock polarity for internal defibrillation: the obvious and non-obvious clinical implications. Pacing Clin. Electrophysiol. 2006 Aug; 29(8):885-91.
Igor Efimov
Low Voltage Defibrillation, Kavli Institute for Theoretical Physics, Santa Barbara, CA, July 27, 2006.
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Efimov IR, Ripplinger CM
Tornado in a dish: revealing the mechanisms of ventricular arrhythmias in engineered cardiac tissues, Cardiovascular Research, 2006, 69(2): 307-8, Editorial.
2006-Efimov-CR.pdf
Fedorov VV, Hucker WJ, Dobrzynski H, Efimov IR
Postganglionic nerve stimulation induces temporal inhibition of excitability in rabbit sinoatrial node. Am J Physiol Heart Circ Physiol. 2006 Aug; 291(2): H612-23.
2006-Fedorov-AJPhys.pdf

2005

Qu F, Li L, Nikolski V, Sharma V, Efimov IR
Mechanisms of Superiority of Ascending Ramp Waveforms: New Insights into Mechanisms of Shock-induced Vulnerability and Defibrillation. Am J Physiol: Heart Circ Physiol. 2005; 289(2): H569-77.
2005-Qu-AJPhys.pdf
Fedorov VV, Li L, Glukhov A, Shishkina I, Aliev RP, Mikheeva T, Nikolski VP, Rosenshtraukh LV, Efimov IR
Hibernator Citellus undulatus maintains safe cardiac conduction and is protected against tachyarrhythmias during extreme hypothermia: possible role of Cx43 and Cx45 upregulation. Heart Rhythm., 2005, 2(9): 966-75.
2005_Heart Rhythm_cover.jpg
2005-Fedorov-HR.pdf
Deng, CX, Qu F, Nikolski VP, Zhou Y, Efimov IR
Fluorescent real-time monitoring of cardiac high-intensity focused ultrasound ablation. Ann. Biomed. Eng, 2005, 33(10): 1417-1424.
2005-Deng-ABE.pdf
Qu F, Zarubin F, Wollenzier B, Nikolski VP, Efimov IR
The Gurvich waveform has lower defibrillation threshold than the rectilinear waveform and the truncated exponential waveform in the rabbit heart. Can J Physiol Pharmacol. 2005; 83: 152-160. PMID: 15791288.
Rodriguez B, Li L, Eason JC, Efimov IR, Trayanova NA
Differences Between Left and Right Ventricular Chamber Geometry Affect Cardiac Vulnerability to Electric Shocks. Circ Res. 2005; 97(2): 168-75. PMCID: PMC2925187.
2005-Circ Res-cover.jpg
2005-Rodriguez-CR.pdf
Dobrzynski H, Li J, Tellez J, Greener ID, Nikolski VP, Wright SE, Parson SH, Jones SA, Lancaster MK, Yamamoto M, Honjo H, Takagishi Y, Kodama I, Efimov IR, Billeter R, Boyett MR
Computer three-dimensional reconstruction of the sinoatrial node. Circulation. 2005; 111: 846-854. PMID: 15699261.
2005-Dobrzynski-JAHA.pdf
Rothenberg F, Nikolski VP, Watanabe M, Efimov IR
Electrophysiology and anatomy of embryonic rabbit hearts before and after septation. Am J Physiol: Heart Circ Physiol. 2005; 288: H344-H351. PMID: 15331361.
2005_Am J Physiol_57_cover.jpg
Rozenshtraukh LV, Fedorov VV, Aliev RR, Glukhov AV, Mikheeva TV, Reznik AV, Efimov IR
[Pattern of Excitation in Isolated Heart of Hibernator Ground Squirrel Citellus undulatus]. Kardiologiia. 2005; 45: 4-10. PMID: 15940184.
Jenkins M, Wade RS, Cheng Y, Rollins AM, Efimov IR
Optical coherence tomography imaging of the Purkinje network. J Cardiovasc Electrophysiol. 2005; 16: 559-560. PMID: 15877631.
Nikolski VP, Efimov IR
Electroporation of the heart. Europace. 2005 (Suppl 2): 146-54.
2005-Nikolski-ESC.pdf
Li L, Nikolski V, Wallick DW, Efimov IR, Cheng Y
Mechanisms of enhanced shock-induced arrhythmogenesis in the rabbit heart with healed myocardial infarction. Am J Physiol: Heart Circ Physiol. 2005, 289(3): H1054-68.
2005-Li-AJPhys.pdf
Igor Efimov
Imaging Arrhythmias: Toward Painless Defibrillation. Cardiac Bioelectricity and Arrhythmia Center, Washington University, St. Louis, MO, October 17, 2005.
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Hucker WJ, Nikolski VP, Efimov IR
Optical mapping of the atrioventricular junction. J. Electrocardiology, 2005, 38S: 121-5. Review.
2005-Hucker-JCE.pdf
Efimov IR, Fedorov VV
Chessboard of atrial fibrillation: Reentry or focus? Single or multiple source(s)? Neurogenic or myogenic? Am. J. Physiol, 2005, 289(3): H977-9. Editorial comment.

2004

Igor Efimov
Cardiac conduction and resistance to ventricular fibrillation in Siberian hibernator Cittelus undulatus: Does the switch from Cx43 to Cx45 improve safety of slow conduction? Life in Cold, Alaska, July 31, 2004
2004-07-31.pdf
Pazo D, Kramer L, Pumir A, Kanani S, Efimov I, Krinsky V
Pinning force in active media. Phys Rev Lett. 2004; 93: 168303. PMID: 15525042.
2004-Pazo-APS.pdf
Rothenberg F, Efimov IR, Watanabe M
Functional imaging of the embryonic pacemaking and cardiac conduction system over the past 150 years: technologies to overcome the challenges. Anat Rec A Discov Mol Cell Evol Biol. 2004; 280: 980-989. PMID: 15372434.
2004-Rothenberg-ARP.pdf
Sambelashvili A, Efimov IR
Dynamics of virtual electrode-induced scroll-wave reentry in a 3D bidomain model. Am J Physiol Heart Circ Physiol. 2004; 287: H1570-H1581. PMID: 15371264.
2004-Sambelashvili-AJPhys.pdf
Sambelashvili AT, Nikolski VP, Efimov IR
Virtual electrode theory explains pacing threshold increase caused by cardiac tissue damage. Am J Physiol Heart Circ Physiol. 2004; 286: H2183-H2194. PMID: 14726298.
2004-Sambelashvili-AJPhys2.pdf
Takagi S, Pumir A, Pazo D, Efimov I, Nikolski V, Krinsky V
Unpinning and removal of a rotating wave in cardiac muscle. Phys Rev Lett. 2004; 93: 058101. PMID: 15323732.
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Takagi S., Pumir A., Pazo D., Efimov I., Nikolski V., Krinsky V
A physical approach to remove anatomical reentries: a bidomain study. J. Theor. Biol., 2004, 230(4): 489-497. PMID: 15363671.
2004-Takagi-JTB.pdf
Efimov IR, Nikolski VP, Salama G
Optical imaging of the heart. Circ Res. 2004 Jul 9; 95(1): 21-33. PMID: 15242982.
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Cheng Y, Li L, Nikolski V, Wallick DW, Efimov IR
Shock-induced arrhythmogenesis is enhanced by 2,3-butanedione monoxime compared with cytochalasin D.Am J Physiol Heart Circ Physiol. 2004; 286(1): H310-8. Epub 2003 Sep 04. PMID: 12958029.
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Efimov IR, Nikolski VP, Rothenberg F, Greener ID, Li J, Dobrzynski H, Boyett M
Structure-function relationship in the AV junction. Anat Rec A Discov Mol Cell Evol Biol. 2004; 280: 952-965. PMID: 15368340.
2004-Efimov-ARP.pdf
Igor Efimov
Cardiac pacing and defibrillation: history and mechanisms of antiarrhythmia therapy, Washington University, MO, September 17, 2004
cardiacpacing.pdf
Nikolski VP, Sambelashvili AT, Krinsky VI, Efimov IR
Effects of electroporation on optically recorded transmembrane potential responses to high-intensity electrical shocks. Am J Physiol Heart Circ Physiol. 2004; 286: H412-H418. PMID: 14527941.
2004-Nikolski-AJPhys.pdf

2003

Dobrzynski H, Nikolski VP, Sambelashvili AT, Greener ID, Yamamoto M, Boyett MR, Efimov IR
Site of origin and molecular substrate of atrioventricular junctional rhythm in the rabbit heart. Circ Res. 2003; 93(11): 1102-10. PMID: 14563715.
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Efimov IR
Fibrillation or neurillation: back to the future in our concepts of sudden cardiac death? Circ Res. 2003; 92(10): 1062-4. PMID: 12775654.
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Igor R. Efimov
Mechanisms of stimulation and defibrillation, Cornell University, NY, March 11, 2003
Sambelashvili AT, Nikolski VP, Efimov IR
Nonlinear effects in subthreshold virtual electrode polarization. Am J Physiol Heart Circ Physiol. 2003; 284(6): H2368-74. PMID: 12742834.
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Igor Efimov
Century of Defibrillation, XII World Congress on Cardiac Pacing & Electrophysiology, Hong Kong, China, February 22, 2003
Garrigue S, Reuter S, Efimov IR, Mazgalev TN, Jais P, Haissaguerre M, Clementy J
Optical mapping technique applied to biventricular pacing: potential mechanisms of ventricular arrhythmias occurrence. Pacing Clin Electrophysiol. 2003; 26(1 Pt 2): 197-205. PMID: 12687812.
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Nikolski VP, Jones SA, Lancaster MK, Boyett MR, Efimov IR
Cx43 and dual-pathway electrophysiology of the atrioventricular node and atrioventricular nodal reentry. Circ Res. 2003; 92(4): 469-75. PMID: 12600895.
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Efimov I.R., Mowrey K.A., Cheng Y., Tchou P.J.
Letter to editor, EuroPACE, 2003, 5(3): 243-244.
Li L, Nikolski V, Efimov IR
Effects of lidocaine on shock-induced vulnerability. J Cardiovasc Electrophysiol. 2003; 14(10 Suppl): S237-48. PMID: 14760929.
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Efimov IR, Nikolski VP
Diastolic shocking experience: do virtual electrodes exist only during systole? J Cardiovasc Electrophysiol. 2003; 14(11): 1223-4. PMID: 14678139.
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News

May, 2013 - Joseph Marmerstein was awarded an AHA fellowship with a proposal entitled, "Sudden Death and the Obesity Paradox in Heart Failure"!!
May, 2013 - Eli Madden was awarded an AHA fellowship with a proposal entitled, "Arrhythmogenic Remodeling and the Obesity Paradox in Human Heart Failure"!!
May, 2013 - Joseph Marmerstein was accepted into the uStar program!!!
April, 2013 - Joseph Marmerstein was awarded a Summer Undergraduate Research Fellowship (SURF) with a proposal entitled, "Sudden Death and the Obesity Paradox in Heart Failure".
April, 2013 - Sarah Gutbrod received the Whitaker International Program Summer Grant Fellowship with a proposal entitled, "Tracking the 3D dynamics of atrial fibrillation and defibrillation patterns"!