EBME 452: PHYSIOLOGICAL PROCESSES II.

Instructor Igor R. Efimov (ire@cwru.edu)

Section 3: Cardiovascular System

 

 

Date Topic Download pdf file Guyton book
2/26 Overview: cardiac pump & excitation Download

Chapter 9 Heart Muscle; The Heart as a Pump

Chapter 10 Rhythmical Excitation of the Heart

Page 96-112

3/2 Electrophysiological analysis Download

Chapter 11 The Normal Electrocardiogram

Chapter 12 Electrocardiographic Interpretation of Cardiac Muscle and Coronary Blood Flow Abnormalities: Vectorial Analysis

Page 114-132

3/4 Cardiac arrhythmias Download

Chapter 13 Cardiac Arrhythmias and Their Electrocardiographic Interpretation

Page 133-142

3/9 Spring break    
3/11 Spring break    
3/16 Hemodynamics Download

Chapter 14 Overview of the Circulation; Medical Physics of Pressure, Flow, and Resistance

Chapter 15 Vascular Distensibility, and Functions of the Arterial and Venous Systems

Page 144-160

3/18 Nervous regulation of the circulation Download

Chapter 18 Nervous Regulation of the Circulation, and Rapid Control of Arterial Pressure

Page 184-194

3/23 Cardiac output & circulation Download

Chapter 20 Cardiac Output, Venous Return, and Their Regulation

Chapter 21 Muscle Blood Flow and Cardiac Output During Exercise; the Coronary Circulation and Ischemic Heart Disease

Page 210-233

3/25 Cardiac failure, defects & shock Download

Chapter 22 Cardiac Failure

Chapter 23 Heart Valve and Heart Sounds; Dynamics of Valvular and Congenital Heart Defects

Chapter 24 Circulatory Shock and Physiology of Its Treatment

Page 235-261

3/30 Genetic basis of cardiac arrhythmias and failure Download Reference 1, 4, 7, and 8

 

Reference:

 

  1. Seidman JG, Seidman C. The genetic basis for cardiomyopathy: from mutation identification to mechanistic paradigms. Cell. 2001; 104: 557-567. [PDF]
  2. Severs NJ. The cardiac muscle cell. Bioessays. 2000; 22: 188-199. [PDF]
  3. Puglisi JL, Bers DM. LabHEART: an interactive computer model of rabbit ventricular myocyte ion channels and Ca transport. Am J Physiol Cell Physiol. 2001; 281: C2049-C2060. [PDF]
  4. Keating MT, Sanguinetti MC. Molecular and cellular mechanisms of cardiac arrhythmias. Cell. 2001; 104: 569-580. [PDF]
  5. Valenzuela TD, Roe DJ, Nichol G, Clark LL, Spaite DW, Hardman RG. Outcomes of rapid defibrillation by security officers after cardiac arrest in casinos. N Engl J Med. 2000; 343: 1206-1209. [PDF]
  6. Mehta NJ, Khan IA, Cardiology’s 10 greatest discoveries of the 20th century, Tex Heart Inst J. 2002: 29(3) 164-171. [PDF]
  7. Silvia G. Priori, Inherited Arrhythmogenic Diseases: The Complexity Beyond Monogenic Disorders. Circulation Research. 2004;94:140. [PDF]
  8. Chen YH, Xu SJ, Bendahhou S, Wang XL, Wang Y, Xu WY, Jin HW, Sun H, Su XY, Zhuang QN, Yang YQ, Li YB, Liu Y, Xu HJ, Li XF, Ma N, Mou CP, Chen Z, Barhanin J, Huang W. KCNQ1 gain-of-function mutation in familial atrial fibrillation. Science. 2003; 299(5604): 251-4. [PDF]