EBME 105 Introduction to Biomedical Engineering

Igor R. Efimov

Cardiac Bioelectricity. 2003

17-Oct Part 1. Cardiovascular disease

Introduction to the heart

Heart disease statistics

Basic and clinical heart research

The role of biomedical engineering

Lecture handout: [PDF-file]

Lecture slides: [HTML-file]

Reading Assignment: Eisenberg MS, Defibrillation: the spark of life, Scientific American, 1998, June: 86-91. [PDF-reprint]

20-Oct No class – Fall break

22-Oct Part 2. Cellular electrophysiology

Cardiac cell membrane biophysics

The cardiac action potential

Genetic basis of the heart disease

(HW #5)

Lecture handout: [PDF-file]

Lecture slides: [HTML-file]

Reading Assignment: Severs NJ. The cardiac muscle cell. Bioessays 2000 Feb;22(2):188-99. [PDF-reprint] : Hille B, Armstrong CM, MacKinnon R. Ion channels: from idea to reality. Nat Med. 1999 Oct;5(10):1105-9. [PDF-reprint]

24-Oct Part 3. Organ electrophysiology and electrocardiography

Excitation-contraction coupling

Action potential propagation

The electrocardiogram (ECG)

Lecture handout: [PDF-file]

Lecture slides: [HTML-file]

Reading Assignment: Keating MT, Sanguinetti MC. Molecular and cellular mechanisms of cardiac arrhythmias. Cell 2001 Feb 23;104(4):569-80. [PDF-reprint]

27-Oct Part 4. Cardiac arrhythmias

Bradycardia

Tachycardia

Fibrillation

Antiarrhythmic therapies

(HW #5 due)

Lecture handout: [PDF-file]

Lecture slides: [HTML-file]

Reading Assignment: Myerburg RJ. Sudden cardiac death: exploring the limits of our knowledge. J Cardiovasc Electrophysiol., 2001 12(3): 369-81. [PDF-reprint]

29-Oct Part 5. Experimental Electrophysiology

Cellular recording techniques

Extracellular recording techniques

Fluorescent molecular probes and imaging

Lecture handout: [PDF-file]

Lecture slides: [HTML-file]

Reading Assignment: Homework reading: Axon Instruments Guide. Chapter 1. http://www.axon.com/pub/axonguide/GuideCh01.pdf

31-Oct Part 6. Electrocardiography

Recording systems

Noninvasive electrocardiography imaging

(HW #6)

Lecture handout: [PDF-file]

Lecture slides: [HTML-file]

Reading Assignment: A brief history of electrocardiography http://www.ecglibrary.com/ecghist.html

3-Nov Part 7. Cardiac implantable devices

Implantable Pacemaker

Implantable Cardioverter Defibrillator

Lecture handout: [PDF-file]

Lecture slides: [HTML-file]

Reading Assignment: Terence D. Valenzuela, et al, Outcomes of Rapid Defibrillation by Security Officers after Cardiac Arrest in Casinos, Volume 343:1206-1209, 2000. [PDF-reprint]

Additional reading (if interested): Page R. L., et al, Use of Automated External Defibrillators by a U.S. Airline, N Engl J Med 2000; 343:1210-1216, 2000. [PDF-reprint]

Buxton A. E., et al, A Randomized Study of the Prevention of Sudden Death in Patients with Coronary Artery Disease. N Engl J Med 1999; 341:1882-1890, Dec 16, 1999. [PDF-reprint]

5-Nov Computer modeling

Reaction-diffusion systems

Cardiac excitation

Reentry

(HW #6 due)

Lecture handout: [PDF-file]

Lecture slides: [HTML-file]

Reading Assignment: Puglisi JL, Bers DM, LabHEART: an interactive computer model of rabbit ventricular myocyte ion channels and Ca transport, Am J Physiol, Cell Physiol, 281: C2049-C2060, 2001 [PDF-reprint]

7-Nov Section Exam

Any questions?

http://efimov.cwru.edu/

mailto:efimov@cwru.edu

Office hours: 10-12 Friday. Wickenden 520.

(c) Igor R. Efimov, Ph.D., 2003